[A simple model of the optimal time for allogenic bone marrow transplantation in chronic granulocytic leukemia].

Abstract

Allogenic bone marrow transplantation is the treatment of choice in chronic granulocyte leukemia patients, while the best results are achieved when it is performed in the chronic phase of the illness. That is why time optimization for bone marrow transplantation in chronic granulocyte leukemia means making priority lists for transplantation according to medical indications. This study comprises a very simple model of optimal time for bone marrow transplantation in chronic granulocyte leukemia. It is based on data of the International Bone Marrow Transplant Registry (IBMTR) on bone marrow transplantation results in different phases of chronic granulocyte leukemia and prognostic model for survival of younger leukemic patients according to which there are three groups of patients. The mathematical method estimated cumulative risks of the final therapeutic results. This model has shown that the time limit for transplantation is the fourth year of the disease in the low risk group; the third year of the disease in the medium risk group and the second year in the high risk group of patients.

• Authors: S Popović, D Pejin, V Uzurov
• Journal: Medicinski pregled (Med Pregl) 1997 Mar-Apr Vol. 50 Issue 3-4 Pg. 100-2 ISSN: 0025-8105 [Print] Serbia
• Vernacular Title: Jednostavni model optimalnog vremena za transplantaciju alogene kostane srzi u hronicnoj granulocitnoj leukemiji.
• PMID: 9229678 (Publication Type: English Abstract, Journal Article)

Topics

• Bone Marrow Transplantation
• Humans
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (therapy)
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Time Factors
• Transplantation, Homologous