Polymorphisms of the human platelet antigens HPA-1, HPA-2, HPA-3, and HPA-5 on the platelet receptors for fibrinogen (GPIIb/IIIa), von Willebrand factor (GPIb/IX), and collagen (GPIa/IIa) are not correlated with an increased risk for stroke.
Abstract | BACKGROUND AND PURPOSE: METHODS:
DNA was isolated from peripheral blood collected from 218 consecutive stroke patients, 165 neurological inpatients without signs of CVD, and 321 healthy blood donors. The genotypes of HPA-1, HPA-2, HPA-3, and HPA-5 were determined by sequence specific primer polymerase chain reactions. RESULTS: The calculated allele frequencies were as follows: for CVD patients, HPA-1a/b 0.81/0.19, HPA-2a/b 0.91/0.09, HPA-3a/b 0.61/0.39, and HPA-5a/b 0.92/0.08; for inpatient HPA-1a/b 0.83/0.17, HPA-2a/b 0.91/0.09, HPA-3a/b 0.62/0.3 and HPA-5a/b 0.93/0.07; and for blood donors, HPA-1a 0.85/0.15, HPA-2a/b 0.94/0.06, HPA-3a/b 0.60/0.40, and HPA 5a/b 0.92/0.08. There were no statistically significant difference for the analyzed HPA polymorphism frequencies either between the CVD patients and the non-CVD inpatients or the CVD patients and blood donors. However, the HPA-1b genotype was slightly more frequent in patients (CVD and non-CVD) than in the healthy blood donors. CONCLUSIONS: Our results indicate that the HPA-1, HPA-2, HPA-3, and HPA-5 polymorphisms are not associated with an increased risk for stroke.
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Authors | L E Carlsson, A Greinacher, C Spitzer, R Walther, C Kessler |
Journal | Stroke
(Stroke)
Vol. 28
Issue 7
Pg. 1392-5
(Jul 1997)
ISSN: 0039-2499 [Print] United States |
PMID | 9227689
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2b alloantigen, human
- 3a alloantigen, human
- 5a alloantigen, human
- Antigens, CD
- Antigens, Human Platelet
- Epitopes
- ITGB3 protein, human
- Integrin alpha2
- Integrin beta3
- Platelet Glycoprotein GPIIb-IIIa Complex
- Platelet Glycoprotein GPIb-IX Complex
- von Willebrand Factor
- Collagen
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Antigens, CD
(genetics, metabolism)
- Antigens, Human Platelet
(genetics, immunology)
- Blood Platelets
(chemistry)
- Cardiovascular Diseases
(epidemiology, genetics)
- Cerebrovascular Disorders
(epidemiology, genetics)
- Collagen
(genetics, metabolism)
- Epitopes
(genetics, immunology)
- Female
- Genotype
- Humans
- Integrin alpha2
- Integrin beta3
- Male
- Middle Aged
- Platelet Glycoprotein GPIIb-IIIa Complex
(genetics)
- Platelet Glycoprotein GPIb-IX Complex
(genetics, metabolism)
- Polymorphism, Genetic
- Risk Factors
- von Willebrand Factor
(genetics, metabolism)
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