Nitrosamines and nitrosamides in the etiology of gastrointestinal cancer.

Abstract

It has been amply demonstrated that N-nitroso compounds are formed by interaction of nitrite with secondary and tertiary amino compounds, and that this reaction can occur in vivo as well as in food processed with nitrite. The favored site of reaction in vivo is the stomach. It is likely that N-nitroso compounds formed in this way, especially nitrosamides, could reach the colon and contribute to the induction of colon tumors.

• Authors: W Lijinsky
• Journal: Cancer (Cancer) Vol. 40 Issue 5 Suppl Pg. 2446-9 (Nov 1977) ISSN: 0008-543X [Print] United States
• PMID: 922686 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amides
• Carcinogens
• Nitrosamines
• Nitroso Compounds

Topics

• Amides (metabolism)
• Animals
• Carcinogens
• Colonic Neoplasms (chemically induced)
• Cricetinae
• Gastrointestinal Neoplasms (chemically induced)
• Guinea Pigs
• Humans
• Nitrosamines (metabolism, pharmacology)
• Nitroso Compounds (metabolism)
• Rats