Age-dependent expression of the apamin-sensitive calcium-activated K+ channel in fast and slow rat skeletal muscle.

Abstract

An altered expression of the apamin-sensitive K+ channel from skeletal muscle is apparently implicated in human myotonic dystrophy (MD). We found, in rats, that the expression of this channel depends on age and the type of muscle. This result may be one of the bases of the different susceptibilities of fast and slow muscles to drug-induced myotonia.

• Authors: C Vergara, B U Ramirez
• Journal: Experimental neurology (Exp Neurol) Vol. 146 Issue 1 Pg. 282-5 (Jul 1997) ISSN: 0014-4886 [Print] United States
• PMID: 9225762 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Potassium Channels
• Apamin

Topics

• Aging (metabolism)
• Animals
• Apamin (metabolism)
• Cell Membrane (metabolism)
• Humans
• Muscle Denervation
• Muscle Development
• Muscle Fibers, Fast-Twitch (metabolism)
• Muscle Fibers, Slow-Twitch (metabolism)
• Muscle, Skeletal (growth & development, innervation, metabolism)
• Myotonic Dystrophy (metabolism)
• Potassium Channels (biosynthesis)
• Rats