HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Protective effects of a thromboxane synthetase inhibitor and continuous arteriovenous hemofiltration in rat endotoxic shock.

Abstract
We determined the efficacy of continuous arteriovenous hemofiltration (CAVH) and a thromboxane synthetase inhibitor (TSI) on survival and their effect on TXA2, PGI2, TNF alpha, and IL-1beta production in rat endotoxemia. Thirty-six endotoxemic rats were randomized to one of 4 groups: (A) no TSI, sham CAVH; (B) no TSI, CAVH; (C) TSI, sham CAVH; and (D) TSI, CAVH. Either CAVH (Group B) or pretreatment with TSI (Group C) resulted in increased survival time. CAVH did not prevent the rise in TX (Group B). TNF alpha levels at 2 h after LPS infusion were higher in Group D compared to Group B (26.1 +/- 3.7 vs 13.2 +/- 4.3 ng/mL, P < 0.05) respectively. IL-1beta was detected earlier in Groups C,D when compared to Groups A,B (P < 0.02). TNF alpha and IL-1beta were not ultrafiltered. CAVH and the inhibition of TX synthesis independently improved survival in endotoxemia, however, their beneficial effects were not additive. While TSI may improve survival by blocking TXA2 production, the salutary effects of CAVH appear to be from removal of an undetermined TXA2 dependent mediator. TNF alpha and IL-1beta concentrations do not appear to influence survival times in this model.
AuthorsS M Heidemann, A P Sarnaik
JournalProstaglandins, leukotrienes, and essential fatty acids (Prostaglandins Leukot Essent Fatty Acids) Vol. 56 Issue 6 Pg. 473-8 (Jun 1997) ISSN: 0952-3278 [Print] Scotland
PMID9223660 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Enzyme Inhibitors
  • Imidazoles
  • Inflammation Mediators
  • Interleukin-1
  • Tumor Necrosis Factor-alpha
  • dazmegrel
  • Thromboxane A2
  • Epoprostenol
  • Thromboxane-A Synthase
Topics
  • Animals
  • Blood Pressure (drug effects)
  • Combined Modality Therapy
  • Enzyme Inhibitors (pharmacology)
  • Epoprostenol (blood)
  • Heart Rate (drug effects)
  • Hemofiltration
  • Imidazoles (pharmacology)
  • Inflammation Mediators (blood)
  • Interleukin-1 (blood)
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Shock, Septic (drug therapy, physiopathology, therapy)
  • Thromboxane A2 (blood)
  • Thromboxane-A Synthase (antagonists & inhibitors)
  • Tumor Necrosis Factor-alpha (biosynthesis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: