The antidysrhythmic aminosteroid, ORG 6001, reduces the ST-segment elevation produced by coronary occlusion in the dog.

Abstract	ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greatly reduced by the prior administration of the anti-dysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.
Authors	R J Marshall, J R Parratt
Journal	British journal of pharmacology (Br J Pharmacol) Vol. 61 Issue 2 Pg. 315-7 (Oct 1977) ISSN: 0007-1188 [Print] England
PMID	922260 (Publication Type: Journal Article)
Chemical References	17-Ketosteroids Androstanes Androstanols Anti-Arrhythmia Agents amafolone
Topics	17-Ketosteroids (pharmacology) Androstanes (pharmacology) Androstanols Animals Anti-Arrhythmia Agents (pharmacology) Arrhythmias, Cardiac (physiopathology) Coronary Vessels (physiology) Dogs Female Hemodynamics (drug effects) Male

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