Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis.

Abstract

9-Hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE) are accumulated in the low density lipoproteins of patients suffering from rheumatoid arthritis for a factor of 20-50 compared to healthy individuals of the same age. Both acids, derived by lipid peroxidation of linoleic acid, induce the release of interleukin 1 beta. The latter induces bone degression. The genesis of 9- and 13-HODE seems therefore to be an important factor in the development and progression of rheuma; in addition 9-HODE was reported to be a stimulus of inflammation, comparable to leukotrienes.

• Authors: W Jira, G Spiteller, A Richter
• Journal: Chemistry and physics of lipids (Chem Phys Lipids) Vol. 87 Issue 1 Pg. 81-9 (May 30 1997) ISSN: 0009-3084 [Print] Ireland
• PMID: 9219348 (Publication Type: Journal Article)

Chemical References

• Aldehydes
• Linoleic Acids
• Linoleic Acids, Conjugated
• Lipid Peroxides
• Lipoproteins, LDL
• 9-hydroxy-10,12-octadecadienoic acid
• 2-hydroxyheptanal
• 13-hydroxy-9,11-octadecadienoic acid
• Linoleic Acid

Topics

• Adult
• Aged
• Aldehydes (blood)
• Arthritis, Rheumatoid (blood)
• Chromatography, Gas
• Female
• Humans
• Linoleic Acid
• Linoleic Acids (blood)
• Linoleic Acids, Conjugated
• Lipid Peroxidation
• Lipid Peroxides (blood)
• Lipoproteins, LDL (blood, chemistry)
• Male
• Mass Spectrometry
• Middle Aged