Abstract | BACKGROUND: METHODS: In this multicentre, double-blind, parallel group, placebo-controlled study, the effect of a single dose of zamifenacin 10 mg or 40 mg on both fasting (30 min) and fed (60 min) colonic motor activity was assessed in 36 patients with irritable bowel syndrome (aged 25-68 years; 19 male). Colonic motility was recorded using a five-channel solid-state catheter introduced by colonoscopy to a depth of 35 cm in an unprepared colon. RESULTS:
Zamifenacin 40 mg profoundly reduced colonic motility, particularly after the meal (P < 0.05). This was reflected by a significant reduction in the mean amplitude of contractions, number of contractions, percentage duration of contractions, activity index and the motility index (P < 0.05). A smaller reduction in all the motility parameters was obtained with 10 mg zamifenacin, but these changes were not statistically significant. Three patients each on placebo and zamifenacin reported side-effects, but these were mild and transient. CONCLUSION:
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Authors | L A Houghton, J Rogers, P J Whorwell, F C Campbell, N S Williams, J Goka |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 11
Issue 3
Pg. 561-8
(Jun 1997)
ISSN: 0269-2813 [Print] England |
PMID | 9218083
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dioxoles
- Muscarinic Antagonists
- Piperidines
- zamifenacin
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Topics |
- Adult
- Aged
- Colonic Diseases, Functional
(drug therapy)
- Dioxoles
(adverse effects, therapeutic use)
- Double-Blind Method
- Humans
- Male
- Middle Aged
- Muscarinic Antagonists
(adverse effects, therapeutic use)
- Piperidines
(adverse effects, therapeutic use)
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