Comparison of the efficacy of diclofenac and betamethasone following strabismus surgery.

Abstract

AIMS:

To compare the relative antiinflammatory potency and safety of topical diclofenac-gentamicin with betamethasone-neomycin following strabismus surgery.

METHODS:

A single centre, single observer, prospective, randomised, and double masked clinical trial of 25 children undergoing bilateral symmetrical horizontal strabismus surgery was carried out. One eye received diclofenac-gentamicin and the contralateral eye received betamethasone-neomycin; both treatments were instilled four times a day for 4 weeks postoperatively. Ocular inflammation was assessed at 1 and 4 weeks postoperatively, objectively by comparison with a photographic chart and subjectively by questionnaire.

RESULTS:

There was no statistically significant difference in the rate of resolution of the inflammatory response between each group at both visits.

CONCLUSION:

Diclofenac appears to be as effective as betamethasone in controlling postoperative inflammation following strabismus surgery and may offer a safer alternative to the use of topical steroids.

• Authors: M Wright, Z Butt, G McIlwaine, B Fleck
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 81 Issue 4 Pg. 299-301 (Apr 1997) ISSN: 0007-1161 [Print] England
• PMID: 9215059 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Gentamicins
• Diclofenac
• Betamethasone
• Neomycin

Topics

• Anti-Bacterial Agents (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Betamethasone (therapeutic use)
• Child
• Child, Preschool
• Diclofenac (therapeutic use)
• Double-Blind Method
• Female
• Gentamicins (therapeutic use)
• Humans
• Infant
• Inflammation (prevention & control)
• Male
• Neomycin (therapeutic use)
• Pain Measurement
• Postoperative Complications (prevention & control)
• Prospective Studies
• Strabismus (surgery)