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Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.

Abstract
Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.
AuthorsT S Wu, M J Liou, C S Kuoh, C M Teng, T Nagao, K H Lee
JournalJournal of natural products (J Nat Prod) Vol. 60 Issue 6 Pg. 606-8 (Jun 1997) ISSN: 0163-3864 [Print] United States
PMID9214732 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Benzofurans
  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • aglafoline
  • rocaglamide
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
  • Benzofurans (isolation & purification, pharmacology)
  • Drug Screening Assays, Antitumor
  • Humans
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Plant Extracts (chemistry)
  • Platelet Aggregation (drug effects)
  • Platelet Aggregation Inhibitors (isolation & purification, pharmacology)
  • Rabbits
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Tumor Cells, Cultured

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