Abstract |
Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b] benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.
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Authors | T S Wu, M J Liou, C S Kuoh, C M Teng, T Nagao, K H Lee |
Journal | Journal of natural products
(J Nat Prod)
Vol. 60
Issue 6
Pg. 606-8
(Jun 1997)
ISSN: 0163-3864 [Print] United States |
PMID | 9214732
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Benzofurans
- Plant Extracts
- Platelet Aggregation Inhibitors
- aglafoline
- rocaglamide
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(isolation & purification, pharmacology)
- Benzofurans
(isolation & purification, pharmacology)
- Drug Screening Assays, Antitumor
- Humans
- In Vitro Techniques
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Mice
- Plant Extracts
(chemistry)
- Platelet Aggregation
(drug effects)
- Platelet Aggregation Inhibitors
(isolation & purification, pharmacology)
- Rabbits
- Spectrophotometry, Infrared
- Spectrophotometry, Ultraviolet
- Tumor Cells, Cultured
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