Injection-associated pain in femoral arteriography: a European multicenter study comparing safety, tolerability, and efficacy of iodixanol and iopromide.

Abstract

PURPOSE:

To evaluate injection-associated pain, safety, and efficacy with the isotonic contrast medium iodixanol (Visipaque 270 mg I/ml) compared with iopromide (Ultravist 300 mg I/ml) in femoral arteriography.

METHODS:

A multicenter, double-blind, randomized, parallel-group clinical investigation was carried out in 54 hospitals in Europe. Of the patients evaluated, 1225 received iodixanol and 1227 iopromide in conventional and/or digital subtraction angiography.

RESULTS:

The iodixanol group reported statistically significantly less injection-associated pain (0.9%) than the iopromide group (9.5%) (p << 0.001). Further, 4.1% in the iodixanol group experienced pain and/or severe heat sensation vs 19. 8% in the iopromide group (p << 0.001). In the iodixanol group, 1.8% of the patients experienced contrast-related adverse events vs 2.4% in the iopromide group (p = NS). Overall diagnostic information was optimal for 94.1% in the iodixanol group and 95.3% in the iopromide group (p = NS).

CONCLUSIONS:

Iodixanol 270 mg I/ml causes significantly less injection-associated pain during femoral arteriography and is as safe and efficacious as iopromide 300 mg I/ml.

• Authors: P Justesen, M Downes, B H Grynne, H Lang, W Rasch, E Seim
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) 1997 Jul-Aug Vol. 20 Issue 4 Pg. 251-6 ISSN: 0174-1551 [Print] United States
• PMID: 9211770 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Contrast Media
• Triiodobenzoic Acids
• Iohexol
• iopromide
• iodixanol

Topics

• Aged
• Contrast Media (adverse effects)
• Double-Blind Method
• Female
• Femoral Artery (diagnostic imaging)
• Humans
• Injections, Intra-Arterial (adverse effects)
• Iohexol (adverse effects, analogs & derivatives)
• Male
• Middle Aged
• Pain (chemically induced)
• Radiography
• Triiodobenzoic Acids (adverse effects)