Effect of a commercial disinfectant ('Virkon') on mouse experimental infection by Cryptosporidium parvum.

Abstract

Cryptosporidium parvum oocysts obtained from naturally-infected calves were exposed to 1-10% 'Virkon' for 10-360 min, then inoculated intragastrically into coccidium-free neonatal mice. Prevalence and intensity of infection were determined seven days later by examination of intestinal homogenates. Although we were unable to abolish infectivity for the mice, the intensity of infection was considerably reduced after long periods of exposure (up to > 90%, depending on disinfectant concentration), indicating that this product may have some value for disinfection when extended exposure is possible (e.g., soaking laboratory glassware).

• Authors: E Ares-Mazás, M J Lorenzo, J A Casal, B Fernández da Ponte, J A Castro, F Freire
• Journal: The Journal of hospital infection (J Hosp Infect) Vol. 36 Issue 2 Pg. 141-5 (Jun 1997) ISSN: 0195-6701 [Print] England
• PMID: 9211161 (Publication Type: Journal Article)

Chemical References

• Disinfectants
• Peroxides
• Sulfuric Acids
• monoperoxysulfate

Topics

• Analysis of Variance
• Animals
• Cryptosporidiosis (prevention & control)
• Cryptosporidium parvum (drug effects)
• Disinfectants (pharmacology)
• Dose-Response Relationship, Drug
• Mice
• Peroxides (pharmacology)
• Statistics, Nonparametric
• Sulfuric Acids (pharmacology)