Abstract |
The in vitro activity of Bay 12-8039, a new oral 8-methoxyquinolone, was compared to the activities of 11 other oral antimicrobial agents ( ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin, azithromycin, clarithromycin, amoxicillin clavulanate, penicillin, cefuroxime, cefpodoxime, and doxycycline) against 250 aerobic and 140 anaerobic bacteria recently isolated from animal and human bite wound infections. Bay 12-8039 was active against all aerobic isolates, both gram-positive and gram-negative isolates, at < or = 1.0 microg/ml (MICs at which 90% of isolates are inhibited [MIC90s < or = 0.25 microg/ml) and was active against most anaerobes at < or = 0.5 microg/ml; the exceptions were Fusobacterium nucleatum and other Fusobacterium species (MIC90s, > or = 4.0 microg/ml) and one strain of Prevotella loeschii (MICs, 2.0 microg/ml). In comparison, the other quinolones tested had similar in vitro activities against the aerobic strains but were less active against the anaerobes, including peptostreptococci, Porphyromonas species, and Prevotella species. The fusobacteria were relatively resistant to all the antimicrobial agents tested except penicillin G (one penicillinase-producing strain of F. nucleatum was found) and amoxicillin clavulanate.
|
Authors | E J Goldstein, D M Citron, M Hudspeth, S Hunt Gerardo, C V Merriam |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 41
Issue 7
Pg. 1552-7
(Jul 1997)
ISSN: 0066-4804 [Print] United States |
PMID | 9210683
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Infective Agents
- Aza Compounds
- Fluoroquinolones
- Quinolines
- Quinolones
- Moxifloxacin
|
Topics |
- Administration, Oral
- Anti-Infective Agents
(pharmacology)
- Aza Compounds
- Bacteria, Aerobic
(drug effects, isolation & purification)
- Bacteria, Anaerobic
(drug effects, isolation & purification)
- Bites and Stings
(microbiology)
- Bites, Human
(microbiology)
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Moxifloxacin
- Quinolines
- Quinolones
(pharmacology)
- Skin Diseases, Bacterial
(drug therapy)
- Soft Tissue Infections
(drug therapy)
- Wound Infection
(drug therapy)
|