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Kenneth MacGredie Memorial Lectureship. Adult T-cell leukemia/lymphoma.

Abstract
Adult T-cell leukemia (ATL) was first reported in Japan, where it has a high incidence in the southwestern region. The retrovirus, human T-lymphotropic virus type I (HTLV-I), is the causative agent of ATL. In ATL-endemic areas, the rate of HTLV-I carriers is high. A definite diagnosis of ATL is based on the presence of HTLV-I proviral DNA in the tumor cell DNA. ATL cells originate from the CD4 subset of peripheral T cells. ATL shows diverse clinical features but can be divided into four subtypes: acute, chronic, smoldering, and lymphoma type. Chemotherapy is not effective; the acute and lymphoma types have a poor prognosis. Familial occurrence of ATL is common. HTLV-I infection is caused by transmission of live infected lymphocytes from mother to child, from man to female, or by blood transfusion. Infection with HTLV-I can lead to other diseases, including HTLV-I-associated myelopathy/tropical spastic paraparesis and HTLV-I uveitis.
AuthorsK Takatsuki
JournalLeukemia (Leukemia) Vol. 11 Suppl 3 Pg. 54-6 (Apr 1997) ISSN: 0887-6924 [Print] England
PMID9209296 (Publication Type: Lecture)
Chemical References
  • DNA, Viral
  • HTLV-I Antibodies
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • DNA, Viral (analysis)
  • Diagnosis, Differential
  • Female
  • HTLV-I Antibodies (blood)
  • Human T-lymphotropic virus 1 (isolation & purification)
  • Humans
  • Incidence
  • Japan (epidemiology)
  • Leukemia-Lymphoma, Adult T-Cell (diagnosis, drug therapy, epidemiology, prevention & control)
  • Male
  • Proviruses (isolation & purification)
  • Survival Rate
  • T-Lymphocytes (pathology)

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