[Inhibition of corneal neovascularization by a new analog of fungal product].

Abstract

The anti-angiogenic activity if FR 118487, a new synthetic analogue of Scolecobasidium arenarium products, was examined in corneas of Japanese white rabbits. We studied locally administered FR 118487 with hydron pellets in two models; corneal neovascularization after implantation of a CuCl2 pellet (CuCl2-induced model) and a Wistar rat's cornea (keratoplasty model) into a rabbit cornea. In the CuCl2-induced model, maximum length of neovascularization was 0.08 +/- 0.10 (mean +/- standard deviation) mm with FR 118487 (control 2.84 +/- 0.13 mm) at 1 week after the implantation. In the keratoplasty model, maximum length of neovascularization was 0.05 +/- 0.05 mm with FR 118487 (control 3.33 +/- 0.18 mm) at 2 weeks after the implantation. In both models, FR 118487 had a significant (p < 0.01) effect on inhibition of corneal neovascularization.

• Authors: S Nii, T Idei, H Terano, Y Mashima
• Journal: Nippon Ganka Gakkai zasshi (Nippon Ganka Gakkai Zasshi) Vol. 101 Issue 6 Pg. 465-9 (Jun 1997) ISSN: 0029-0203 [Print] Japan
• PMID: 9209132 (Publication Type: English Abstract, Journal Article)

Chemical References

• FR 118487
• Spiro Compounds
• Copper
• cuprous chloride

Topics

• Animals
• Copper
• Corneal Neovascularization (chemically induced, drug therapy)
• Corneal Transplantation (adverse effects)
• Disease Models, Animal
• Female
• Fungi
• Rabbits
• Rats
• Rats, Wistar
• Spiro Compounds (therapeutic use)