Abstract |
A thirty-fold or even greater increase in plasma beta-2-microglobulin (beta 2M), which is commonly found in end-stage renal disease ( ESRD) patients on long-term hemodialysis (HD), is most likely a consequence of the inability of the dialysis procedure to remove the dally production of beta 2M. In the present study, a newly developed high-flux membrane composed of cellulose diacetate (CDA) (dialyzer Plivadial Altra-Flux 140, Pliva, Zagreb, Croatia) was evaluated with regard to beta 2M removal capacity during HD in 8 stable ESRD patients. Thera was a drop in the plasma beta 2M concentration (-19.8 +/- 8.4) with a clearance of 22.7 +/- 9.2 ml/min (QB = 250 ml/min, QD = 600 ml/min). Accordingly, the sieving coefficient (SC) was found to be 0.37 +/- 0.1 at 60 min after the start of HD. The CDA membrane was able to remove 100.5 +/- 30 mg of beta 2M during a 4-hour HD session. This data demonstrate an increased percentage removal of beta 2M and significantly decreased postdialysis plasma concentrations of beta 2M which is a potential factor in the development of dialysis-related amyloidosis (DRA).
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Authors | P Kes, A Zubcić, I Ratković-Gusić, M Prsa, S Sefer |
Journal | Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti
(Acta Med Croatica)
Vol. 51
Issue 2
Pg. 105-9
( 1997)
ISSN: 1330-0164 [Print] Croatia |
PMID | 9204596
(Publication Type: Journal Article)
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Chemical References |
- Membranes, Artificial
- beta 2-Microglobulin
- Cellulose
- cellulose diacetate
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Topics |
- Adult
- Cellulose
(analogs & derivatives)
- Female
- Humans
- Kidney Failure, Chronic
(blood, therapy)
- Male
- Membranes, Artificial
- Middle Aged
- Renal Dialysis
(instrumentation)
- beta 2-Microglobulin
(analysis)
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