Abstract | BACKGROUND: OBJECTIVE: We assessed, in healthy volunteers, the skin irritancy potential of three combinations, each including adapalene 0.1% gel and one topical marketed antiacne product. METHODS: Twenty-five healthy volunteers were enrolled in a 21-day cumulative irritancy study performed in a double-blind, randomized, controlled, intraindividual design. Five days a week, the three materials ( benzoyl peroxide, clindamycin phosphate, and erythromycin) were applied in a nonocclusive manner either alone or in combination with adapalene gel on seven cutaneous sites on the upper back. Adapalene was applied in the evening whereas the three other materials were applied in the morning. Irritation was evaluated and scored daily except on weekends. RESULTS: CONCLUSION: Under the conditions of the study, all tested treatments alone or in combination appeared nonirritating.
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Authors | D Caron, V Sorba, A Clucas, M Verschoore |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 36
Issue 6 Pt 2
Pg. S113-5
(Jun 1997)
ISSN: 0190-9622 [Print] United States |
PMID | 9204088
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Gels
- Keratolytic Agents
- Naphthalenes
- Adapalene
- Clindamycin
- Erythromycin
- clindamycin phosphate
- Benzoyl Peroxide
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Topics |
- Adapalene
- Administration, Topical
- Adult
- Anti-Bacterial Agents
(pharmacology)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Benzoyl Peroxide
(pharmacology)
- Clindamycin
(analogs & derivatives, pharmacology)
- Double-Blind Method
- Erythromycin
(pharmacology)
- Female
- Gels
- Humans
- Keratolytic Agents
(pharmacology)
- Male
- Middle Aged
- Naphthalenes
(administration & dosage)
- Skin
(drug effects)
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