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Intracisternal injection of basic fibroblast growth factor reduces the severity of gastric mucosal lesions evoked by ethanol in rats.

Abstract
This study was conducted to examine the hypothesis that basic fibroblast growth factor (bFGF) may have an anti-ulcer action through an acid-independent mechanism. The intracisternal injection of bFGF (1 microgram/10 microliters) significantly attenuated the development of gastric mucosal damage evoked by either subcutaneous indomethacin or intragastric absolute ethanol. On the other hand, intraperitoneally injected bFGF (1 microgram) failed to inhibit the formation of gastric mucosal injury by indomethacin or ethanol. These results suggest that bFGF acts in the brain to exert a gastroprotective action. Since ethanol-induced gastric lesion formation does not depend upon luminal acid, we speculate that an acid-independent mechanism may mediate the anti-ulcer action of central bFGF.
AuthorsY Watanabe, T Okumura, S Onodera, N Takahashi, E Shoji, Y Kohgo
JournalThe Japanese journal of physiology (Jpn J Physiol) Vol. 47 Issue 2 Pg. 231-3 (Apr 1997) ISSN: 0021-521X [Print] Japan
PMID9201552 (Publication Type: Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Fibroblast Growth Factor 2
  • Ethanol
  • Indomethacin
Topics
  • Animals
  • Anti-Ulcer Agents (administration & dosage, pharmacology, therapeutic use)
  • Brain (drug effects, physiology)
  • Cisterna Magna
  • Disease Models, Animal
  • Ethanol (administration & dosage, toxicity)
  • Fibroblast Growth Factor 2 (administration & dosage, pharmacology, therapeutic use)
  • Gastric Acid (metabolism)
  • Gastric Mucosa (drug effects, pathology)
  • Indomethacin (administration & dosage, toxicity)
  • Injections, Intraperitoneal
  • Injections, Intraventricular
  • Injections, Subcutaneous
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Stomach Ulcer (chemically induced, drug therapy)

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