Abstract |
Experiments were conducted to determine effects of Santoquin ( ethoxyquin) and oxidized fat on liver and intestinal reduced (GSH) and oxidized ( GSSG) glutathione, and pulmonary hypertension syndrome (PHS) mortality. Male broilers were randomly assigned in a 2 x 2 factorial consisting of 3.5% normal (NF) or oxidized (OxF) fat with or without ethoxyquin (E). Body weights and feed intake were monitored weekly, and tissues obtained at 3 and 7 wk for GSH and GSSG analysis. Compared to the NF group, NF/E gained more weight during the starter (0 to 3 wk), but not the grower (4 to 7 wk) period. Birds fed NF/E or NF exhibited greater feed efficiency in the starter period and greater gains during the starter and grower periods than birds fed OxF or OxF/E. No differences in PHS mortality between treatments were observed. Birds fed OxF exhibited lower liver GSSG at 3 wk than the other groups, but there were no differences in liver GSH. Duodenal GSH was higher in birds fed OxF/E than in birds of NF group at 3 and 7 wk. Ileal GSH was higher at 3 wk in OxF/E birds than in OxF birds, but no differences were observed at 7 wk. All tissues exhibited higher GSH levels at 7 wk than at 3 wk. Birds fed ethoxyquin, regardless of fat source, exhibited higher duodenal GSH at 3 and 7 wk and higher ileal GSH at 3 wk than birds that did not receive ethoxyquin. Higher GSH would be beneficial by enhancing protection of intestinal cells to deleterious effects of toxins or other forms of oxidative stress.
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Authors | S Y Wang, W Bottje, P Maynard, J Dibner, W Shermer |
Journal | Poultry science
(Poult Sci)
Vol. 76
Issue 7
Pg. 961-7
(Jul 1997)
ISSN: 0032-5791 [Print] England |
PMID | 9200231
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Dietary Fats
- Lipid Peroxides
- Ethoxyquin
- Glutathione
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Chickens
(metabolism, physiology)
- Diet
(veterinary)
- Dietary Fats
(metabolism, pharmacology)
- Eating
(physiology)
- Ethoxyquin
(pharmacology)
- Glutathione
(analysis, metabolism)
- Hematocrit
- Hypertension, Pulmonary
(epidemiology, physiopathology, veterinary)
- Incidence
- Intestinal Mucosa
(metabolism)
- Intestines
(chemistry, drug effects)
- Lipid Peroxides
(blood)
- Liver
(chemistry, drug effects, metabolism)
- Male
- Oxidation-Reduction
- Oxidative Stress
(physiology)
- Poultry Diseases
(epidemiology, mortality, physiopathology)
- Random Allocation
- Syndrome
- Weight Gain
(physiology)
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