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[Cytomegalovirus infection in neonates. Diagnosis and therapeutic experiences].

Abstract
Approximately 0.5-1% of all newborns are born infected with cytomegalovirus (CMV), but of these only one out of ten show symptoms at birth, most often with hepatosplenomegaly, thrombocytopenia, and/or brain affection. Of the remaining nine, one may later develop sequelae with hearing loss and/or mental retardation. CMV infection may also be acquired perinatally or in the newborn period, and may cause pneumonia and/or sepsis, possibly also gastrointestinal symptoms like blood in the stool, and poor weight-gain. We have diagnosed CMV infection in ten neonates and infants, and describe these patients in terms of symptoms, diagnosis and treatment. Ganciclovir is being tested in clinical trials as a treatment for congenital CMV infection, and was given to two of our patients with apparently good results.
AuthorsR B Fjaer, T G Abrahamsen, A L Bruu, T W Hansen
JournalTidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke (Tidsskr Nor Laegeforen) Vol. 117 Issue 10 Pg. 1460-4 (Apr 20 1997) ISSN: 0029-2001 [Print] Norway
Vernacular TitleCytomegalovirusinfeksjon hos nyfødte. Erfaringer med diagnostikk og behandling.
PMID9198923 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antiviral Agents
  • Ganciclovir
Topics
  • Antiviral Agents (therapeutic use)
  • Cytomegalovirus Infections (diagnosis, drug therapy)
  • Female
  • Ganciclovir (therapeutic use)
  • Gastrointestinal Diseases (diagnosis, drug therapy)
  • Humans
  • Infant, Newborn

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