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Anti-oxidative therapy with oral dapsone improved HCV antibody positive annular elastolytic giant cell granuloma.

Abstract
A 72-year-old fisherman who was positive for the HCV antibody developed an annular, erythematous, infiltrated lesions on sun-exposed areas. The lesions were diagnosed as annular elastolytic giant cell granuloma both clinically and histologically. Topical corticosteroid and cryotherapy with liquid nitrogen for several months failed to improve the lesions. We then started dapsone, a known anti-oxidant, at 50 mg/day. A month later, the margins of the erythematous lesions faded, and the infiltration gradually decreased. No recurrence has been observed for one year after the start of the therapy. Anti-oxidative therapy appears to be effective for annular elastolytic giant cell granuloma and could be an alternate therapy for refractory granulomatous disease.
AuthorsK Igawa, R Maruyama, I Katayama, K Nishioka
JournalThe Journal of dermatology (J Dermatol) Vol. 24 Issue 5 Pg. 328-31 (May 1997) ISSN: 0385-2407 [Print] England
PMID9198323 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antioxidants
  • Folic Acid Antagonists
  • Hepatitis C Antibodies
  • Dapsone
Topics
  • Administration, Oral
  • Aged
  • Antioxidants (therapeutic use)
  • Dapsone (therapeutic use)
  • Elastic Tissue (drug effects, pathology)
  • Folic Acid Antagonists (therapeutic use)
  • Granuloma Annulare (complications, drug therapy, pathology)
  • Granuloma, Giant Cell (complications, drug therapy, pathology)
  • Hepacivirus (immunology)
  • Hepatitis C (complications)
  • Hepatitis C Antibodies (immunology)
  • Humans
  • Male
  • Skin Diseases (complications, drug therapy, pathology)

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