Abstract |
Investigations using 3H-Arteparon (3H-glycosaminoglycan polysulfate, 3H-GAGPS) showed that in humans with degenerative joint disease an intramuscular administration of 125 mg GAGPS (0.5 ml Arteparon forte) produces GAGPS concentrations within the joint, which in a biochemical assay inhibit cartilage degrading lysosomal enzymes. The dosage was determined from animal experiments that had indicated the relationship between the applied quantity of the drug and the resulting biological concentrations. Preliminary results of treatment with 0.5 ml Arteparon forte in 15 patients are reported.
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Authors | G L Bach, P Panse, P Zeiller |
Journal | Zeitschrift fur Rheumatologie
(Z Rheumatol)
1977 Jul-Aug
Vol. 36
Issue 7-8
Pg. 269-74
ISSN: 0340-1855 [Print] Germany |
Vernacular Title | Glykosaminoglykanpolysulfat (GAGPS, Arteparon) zur Basistherapie der Arthrose. III. Biochemisch-diagnostische und klinische Untersuchungen zur intramuskulären Anwendung von GAGPS. |
PMID | 919801
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Glycosaminoglycans
- Glucuronidase
- Peptide Hydrolases
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Topics |
- Animals
- Dose-Response Relationship, Drug
- Enzyme Repression
(drug effects)
- Glucuronidase
- Glycosaminoglycans
(administration & dosage, metabolism, therapeutic use)
- Humans
- Injections, Intramuscular
- Lysosomes
(drug effects)
- Osteoarthritis
(drug therapy)
- Peptide Hydrolases
- Rabbits
- Synovial Fluid
(chemistry)
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