Abstract |
Cerebrospinal fluid (CSF) samples were collected from monkeys infected with SIVmac251 (SIV) or HIV-1/SIVmac chimeric viruses (SHIV(HXBc2) and SHIV(89.6P)) to investigate quinolinic acid (QUIN) levels in the intrathecal compartment. CSF levels of QUIN were elevated in the SIV-infected monkeys, especially in animals with end-stage disease, and in those infected with pathogenic SHIV(89.6P), but not after infection with the nonpathogenic construct SHIV(HXBc2). QUIN elevations occurred in association with reduced CD4+ and increased CD8+ lymphocytes, cellular alterations that were more pronounced in CSF than in the blood. These findings support the view that the intrathecal compartment provides a unique window on viral infection, and are in keeping with the a priori prediction that QUIN increases primarily in response to more pathogenic viral strains.
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Authors | C L Coe, T M Reyes, C D Pauza, J F Reinhard Jr |
Journal | AIDS research and human retroviruses
(AIDS Res Hum Retroviruses)
Vol. 13
Issue 10
Pg. 891-7
(Jul 01 1997)
ISSN: 0889-2229 [Print] United States |
PMID | 9197383
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biomarkers
- Quinolinic Acid
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Topics |
- Animals
- Biomarkers
(cerebrospinal fluid)
- Blood-Brain Barrier
- CD4-CD8 Ratio
- Lymphocyte Subsets
- Macaca mulatta
- Male
- Quinolinic Acid
(cerebrospinal fluid)
- Simian Acquired Immunodeficiency Syndrome
(cerebrospinal fluid, immunology, virology)
- Simian Immunodeficiency Virus
(pathogenicity)
- Virulence
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