A seven days course of eflornithine for relapsing Trypanosoma brucei gambiense sleeping sickness.

Forty-seven patients with a relapse following a first treatment of Trypanosoma brucei gambiense trypanosomiasis were treated with a 7 d course of intravenous eflornithine (100 mg/kg every 6 h) and followed for 2 years. Four patients died after treatment, 2 of them possibly due to trypanosomiasis. One patient was completely lost to follow-up, 36 were followed for at least one year, and 25 have completed the 2 years' follow-up. Only one patient, a 5 years old child, subsequently relapsed. Considering this child and 2 of the fatalities as treatment failures, the rate of failure was 6.5%. A 7 d course of intravenous eflornithine is an adequate treatment for cases of Gambian trypanosomiasis relapsing after treatment with another drug.
AuthorsN Khonde, J Pépin, B Mpia
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) 1997 Mar-Apr Vol. 91 Issue 2 Pg. 212-3 ISSN: 0035-9203 [Print] ENGLAND
PMID9196773 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Trypanocidal Agents
  • Eflornithine
  • Adolescent
  • Adult
  • Aged
  • Animals
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Eflornithine (administration & dosage, therapeutic use)
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Recurrence
  • Treatment Failure
  • Trypanocidal Agents (administration & dosage, therapeutic use)
  • Trypanosoma brucei gambiense
  • Trypanosomiasis, African (cerebrospinal fluid, drug therapy, parasitology)

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