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Prospective use of intramuscular triamcinolone acetonide in pseudogout.

AbstractOBJECTIVE:
To prospectively assess the efficacy of intramuscular (i.m.) triamcinolone acetonide in the treatment of pseudogout.
METHODS:
Fourteen patients with crystal proven pseudogout presenting with an acute attack within 5 days of onset were treated with intramuscular triamcinolone acetonide 60 mg and followed for 30 days. Patients with inadequate response were eligible for a 2nd triamcinolone acetonide injection on Day 1-2.
RESULTS:
Twelve patients had contraindication to nonsteroidal antiinflammatory agents (NSAID). Acute arthritis was monoarticular in 10 patients, and involved 2 or more joints in 4 patients. All patients had good clinical response to triamcinolone acetonide based on restoration of near baseline joint range of motion and joint circumference, and at least 50% improvement in patient and physician global assessment. Major clinical improvement occurred by Day 1-2 (2 patients), Day 3-4 (11 patients), and Day 10-14 (one patient). Six patients required a 2nd triamcinolone acetonide injection on Day 1-2. Toxicities were not observed.
CONCLUSION:
I.m. triamcinolone acetonide appears to be safe, well tolerated, and effective in the treatment of pseudogout. It may be a reasonable alternative therapy when NSAID are contraindicated, and for polyarticular attacks where intraarticular corticosteroids are impractical.
AuthorsD W Roane, M D Harris, M T Carpenter, D R Finger, M J Jarek, J A Alloway, A R Erickson, W E Venanzi, T J Drehmer
JournalThe Journal of rheumatology (J Rheumatol) Vol. 24 Issue 6 Pg. 1168-70 (Jun 1997) ISSN: 0315-162X [Print] Canada
PMID9195527 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Triamcinolone Acetonide
Topics
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents (therapeutic use)
  • Chondrocalcinosis (drug therapy)
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Prospective Studies
  • Triamcinolone Acetonide (therapeutic use)

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