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HLA-B27 subtypes positively and negatively associated with spondyloarthropathy.

AbstractOBJECTIVE:
Eleven subtypes of HLA-B27 have been identified. If some of these subtypes had a stronger association with spondyloarthropathy (SpA) than others, this might tell us which peptides are of pathogenetic importance. A subtype preponderance has not been proved in Caucasians or in Asian Indians. Our objective was to determine whether some subtypes are positively or negatively associated with SpA in Indonesia.
METHODS:
Cells of 34 HLA-B27 positive patients with SpA (fulfilling the European Spondylarthropathy Study Group criteria) and 26 HLA-B27 positive controls, all living in Java, Indonesia, were sampled. Patients and controls were divided according to their presumed ethnic origin. HLA-B27 subtyping (B*2701-09) was performed by polymerase chain reaction in combination with sequence specific oligonucleotide probes to analyze polymorphism in exons 2 and 3 of HLA-B27.
RESULTS:
HLA-B*2701, *2702, *2703, *2708, and *2709 were found in neither group. HLA-B*2704 was found in 23/34 (68%) of the patients and in only 4/26 (15%) of the controls (p < 0.01). HLA-B*2706 was found in none of the 34 patients, but in 21/26 (81%) of the controls (p < 0.01). One drawback of the study was that most patients were of Chinese descent and most controls were native Javanese. Nevertheless, the absence of SpA among HLA-B*2706 positive individuals is noteworthy.
CONCLUSION:
HLA-B*2704 is positively associated with SpA (RR = 11.5), while *2706 is negatively associated with this disease (RR < 0.007). The results confirm the findings of Lopez-Larrea, et al in Thailand.
AuthorsA R Nasution, A Mardjuadi, S Kunmartini, N G Suryadhana, B Setyohadi, D Sudarsono, N M Lardy, T E Feltkamp
JournalThe Journal of rheumatology (J Rheumatol) Vol. 24 Issue 6 Pg. 1111-4 (Jun 1997) ISSN: 0315-162X [Print] Canada
PMID9195518 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HLA-B27 Antigen
Topics
  • HLA-B27 Antigen (genetics, isolation & purification)
  • Humans
  • Indonesia
  • Spondylitis, Ankylosing (ethnology, metabolism)

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