Abstract | BACKGROUND: METHODS: Thirty-eight acutely psychotic and neuroleptic responsive (by history) newly admitted inpatients with schizophrenia were randomized to 4 weeks of double-blind treatment (2:1) with either L-745,870 (n = 26), 15 mg/d, or placebo (n = 12) after a 3- to 5-day placebo run-in period. RESULTS: Overall, a greater percentage of patients receiving L-745,870 compared with patients receiving placebo discontinued the study for insufficient therapeutic response (32% vs 16%). At the end of 4 weeks by last observation carried forward analysis, the mean change from baseline to week 4 on the total Brief Psychiatric Rating Scale favored placebo (i.e., -8 points [-15% change from baseline] vs -1 point [-2% change from baseline] for placebo vs L-745,870, P = .09). Similar differences in favor of placebo in changes from baseline mean scores were observed for the not carried forward analysis on the total Brief Psychiatric Rating Scale (P < .03), for not carried forward and last observation carried forward analyses on the sum of selected positive symptom items of the Brief Psychiatric Rating Scale, and for the Clinical Global Impression analysis (P = .03, last observation carried forward). A greater percentage of patients receiving L-745,870 had scores indicative of some level of worsening (compared with baseline) on the total Brief Psychiatric Rating Scale and the Clinical Global Impressions' Severity of Illness Scale as well as positive symptoms compared with those receiving placebo. CONCLUSION:
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Authors | M S Kramer, B Last, A Getson, S A Reines |
Journal | Archives of general psychiatry
(Arch Gen Psychiatry)
Vol. 54
Issue 6
Pg. 567-72
(Jun 1997)
ISSN: 0003-990X [Print] United States |
PMID | 9193198
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antipsychotic Agents
- DRD4 protein, human
- Dopamine Antagonists
- Placebos
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Chloral Hydrate
- Lorazepam
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Topics |
- Acute Disease
- Adult
- Antipsychotic Agents
(pharmacology, therapeutic use)
- Chloral Hydrate
(therapeutic use)
- Dopamine Antagonists
(therapeutic use)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Hospitalization
- Humans
- Lorazepam
(therapeutic use)
- Male
- Placebos
- Psychiatric Status Rating Scales
- Receptors, Dopamine D2
(drug effects)
- Receptors, Dopamine D4
- Schizophrenia
(diagnosis, drug therapy)
- Schizophrenic Psychology
- Severity of Illness Index
- Treatment Outcome
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