Abstract | PURPOSE: MATERIAL AND METHODS: A rat model of an experimental HCC was used. CT was performed before and after an i.v. bolus injection of 1.0 ml FP 736-03/kg b.w. Attenuation values of normal liver parenchyma and tumour tissue were measured over time. RESULTS: The contrast medium was taken up by the normal liver parenchyma but not by the tumour tissue for which the attenuation remained virtually constant over the observation period. CONCLUSION: The study demonstrated that FP 736-03 was not taken up by the HCC, thus producing a high lesion-to-liver contrast.
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Authors | A Bergman, A Sundin, A Magnusson |
Journal | Acta radiologica (Stockholm, Sweden : 1987)
(Acta Radiol)
Vol. 38
Issue 3
Pg. 400-4
(May 1997)
ISSN: 0284-1851 [Print] England |
PMID | 9191430
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Emulsions
- Fat Emulsions, Intravenous
- Phospholipids
- iodized oil, phospholipid, cholesterol emulsion
- Iodized Oil
- Cholesterol
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Topics |
- Animals
- Cholesterol
(pharmacokinetics)
- Contrast Media
(pharmacokinetics)
- Emulsions
- Fat Emulsions, Intravenous
(pharmacokinetics)
- Female
- Injections, Intravenous
- Iodized Oil
(pharmacokinetics)
- Liver
(diagnostic imaging, metabolism, pathology)
- Liver Neoplasms, Experimental
(diagnostic imaging)
- Phospholipids
- Radiographic Image Enhancement
(methods)
- Rats
- Rats, Inbred Strains
- Time Factors
- Tomography, X-Ray Computed
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