CT of experimental hepatoma using the hepatocyte-specific lipid emulsion FP 736-03.

Abstract

PURPOSE:

The aim of the study was to investigate whether moderately to well differentiated hepatocellular carcinomas (HCC) possess the same ability to take up a new lipid emulsion contrast medium, FP 736-03, as do hepatocytes.

MATERIAL AND METHODS:

A rat model of an experimental HCC was used. CT was performed before and after an i.v. bolus injection of 1.0 ml FP 736-03/kg b.w. Attenuation values of normal liver parenchyma and tumour tissue were measured over time.

RESULTS:

The contrast medium was taken up by the normal liver parenchyma but not by the tumour tissue for which the attenuation remained virtually constant over the observation period.

CONCLUSION:

The study demonstrated that FP 736-03 was not taken up by the HCC, thus producing a high lesion-to-liver contrast.

• Authors: A Bergman, A Sundin, A Magnusson
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 38 Issue 3 Pg. 400-4 (May 1997) ISSN: 0284-1851 [Print] England
• PMID: 9191430 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Emulsions
• Fat Emulsions, Intravenous
• Phospholipids
• iodized oil, phospholipid, cholesterol emulsion
• Iodized Oil
• Cholesterol

Topics

• Animals
• Cholesterol (pharmacokinetics)
• Contrast Media (pharmacokinetics)
• Emulsions
• Fat Emulsions, Intravenous (pharmacokinetics)
• Female
• Injections, Intravenous
• Iodized Oil (pharmacokinetics)
• Liver (diagnostic imaging, metabolism, pathology)
• Liver Neoplasms, Experimental (diagnostic imaging)
• Phospholipids
• Radiographic Image Enhancement (methods)
• Rats
• Rats, Inbred Strains
• Time Factors
• Tomography, X-Ray Computed