Abstract |
Since November 1996, there has been a nationwide shortage of intravenous (IV) multivitamins (MVIs) used in U.S. hospitals and home-health-care agencies for total parenteral nutrition (TPN). Patients receiving TPN without MVI supplementation are at risk for thiamine deficiency and life-threatening complications associated with severe deficiency of thiamine, a coenzyme necessary for oxidation of keto acids (Figure 1). This report describes three patients receiving TPN who had thiamine deficiency-related lactic acidosis in 1997 and presents recommendations for alternatives to parenteral MVI during the shortage.
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Authors | Centers for Disease Control and Prevention (CDC) |
Journal | MMWR. Morbidity and mortality weekly report
(MMWR Morb Mortal Wkly Rep)
Vol. 46
Issue 23
Pg. 523-8
(Jun 13 1997)
ISSN: 0149-2195 [Print] United States |
PMID | 9191033
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Acidosis, Lactic
(etiology)
- Adult
- Child
- Female
- Humans
- Male
- Parenteral Nutrition, Total
- Thiamine Deficiency
(complications, prevention & control)
- United States
- Vitamins
(supply & distribution)
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