History of vitamin D treatment of renal osteodystrophy.

Abstract

Vitamin D treatment was tried when renal osteodystrophy was first recognized in the early 20th century, using vitamin D2, D3, or dihydrotachysterol. Large doses of vitamin D2 or D3 (150,000-500,000 IU) were prescribed by monitoring serum calcium, phosphate, and alkaline phosphatase. After the discovery of 1,25-dihydroxycholecalciferol, this compound or 1 alpha-hydroxycholecalciferol was applied to the treatment of renal osteodystrophy. In a preclinical study, especially of 1 alpha-hydroxycholecalciferol, nephritogenoside nephritis was the most responsive condition. These active vitamin D preparations are now widely used in patients with chronic renal failure under hemodialysis. Other active vitamin D compounds, such as hexafluoro-1,25-dihydroxycholecalciferol and 22-oxacalcitriol, are also under investigation.

• Authors: H Morii, E Ishimura, T Inoue, T Tabata, A Morita, Y Nishii, M Fukushima
• Journal: American journal of nephrology (Am J Nephrol) Vol. 17 Issue 3-4 Pg. 382-6 ( 1997) ISSN: 0250-8095 [Print] Switzerland
• PMID: 9189258 (Publication Type: Historical Article, Journal Article)

Chemical References

• Vitamin D

Topics

• Animals
• Chronic Kidney Disease-Mineral and Bone Disorder (drug therapy, history)
• History, 20th Century
• Humans
• Vitamin D (history, therapeutic use)