Prediction of postoperative decompensated liver function by technetium-99m galactosyl-human serum albumin liver scintigraphy in patients with hepatocellular carcinoma complicating chronic liver disease.

Abstract

BACKGROUND:

Preoperative technetium-99m galactosyl-human serum albumin (Tc-GSA) liver scintigraphy may predict postoperative decompensated liver function and its value has been investigated in patients having resection of hepatocellular carcinoma (HCC).

METHODS:

Hepatic uptake ratio of Tc-GSA (LHL15) was measured before operation in 30 patients. Postoperative complications were analysed retrospectively and compared with LHL15 values and other indicators evaluating hepatic function.

RESULTS:

The LHL15 of 22 patients without complications was 0.91 or more, compared with 0.90 or less in the eight patients who had complications. Multifactorial analyses showed that LHL15 and Child-Pugh grade significantly predicted postoperative complications (P < 0.0001 and P = 0.0111 respectively). LHL15 was a significant predictor of complications in patients with Child-Pugh grade B disease (n = 15, P = 0.0011).

CONCLUSION:

LHL15 was a reliable preoperative indicator of the risk of major postoperative complications in patients who had resection for HCC.

• Authors: Y K Kim, H Nakano, M Yamaguchi, K Kumada, S Takeuchi, N Kitamura, H Takahashi, S Hasebe, T Midorikawa, Y Sanada
• Journal: The British journal of surgery (Br J Surg) Vol. 84 Issue 6 Pg. 793-6 (Jun 1997) ISSN: 0007-1323 [Print] England
• PMID: 9189089 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Technetium Tc 99m Aggregated Albumin
• technetium Tc 99m DTPA-galactosyl-human serum albumin
• Technetium Tc 99m Pentetate

Topics

• Aged
• Blood Loss, Surgical
• Carcinoma, Hepatocellular (diagnostic imaging, physiopathology, surgery)
• Chronic Disease
• Hepatitis (complications)
• Humans
• Liver Cirrhosis (complications)
• Liver Function Tests
• Liver Neoplasms (diagnostic imaging, physiopathology, surgery)
• Middle Aged
• Patient Selection
• Postoperative Complications (physiopathology)
• Preoperative Care
• Radionuclide Imaging
• Retrospective Studies
• Technetium Tc 99m Aggregated Albumin
• Technetium Tc 99m Pentetate