Anti-emetic drug effects on cognitive and psychomotor performance: granisetron vs. ondansetron.

The central objectives of this study were to evaluate the cognitive, psychomotor and subjective effects of two anti-emetic drugs of established value in the prophylaxis of radiation induced nausea and vomiting. The drugs of interest were granisetron (Kytril, SmithKline Beecham Pharmaceuticals, Philadelphia, PA; 1 mg tablets/2 mg dose) and ondansetron (Zofran, Glaxo Welcome, Inc., Research Triangle Park, NC; 8 mg tablets/8 mg dose). The experimental approach, involving 24 active-duty military subjects, was a placebo controlled, double blind, crossover design with a positive control (prochlorperazine, 10 mg tablets/10 mg dose) condition. Testing was accomplished during the evening and early morning hours, between 1630 hours and 0230 hours. Therefore, fatigue stemming from an extended work period and a disrupted work/rest cycle was also part of the study design. Data were collected on the following: cognitive and psychomotor effects, affective state changes, temperature, serum drug levels, and side effects. The drugs of interest, granisetron and ondansetron, were extremely well tolerated, with no obvious side effects when compared to the placebo condition. Two of five cognitive tests detected a positive control effect and nearly all of the measurement instruments demonstrated a general fatigue effect, independent of the drug. There was no evidence of any cognitive, psychomotor or subjective state changes caused by either granisetron or ondansetron. It was concluded the anti-emetic drugs, granisetron or ondansetron, would not interfere with performance when given prophylactically to personnel at risk of exposure to radiation.
AuthorsT A Benline, J French
JournalAviation, space, and environmental medicine (Aviat Space Environ Med) Vol. 68 Issue 6 Pg. 504-11 (Jun 1997) ISSN: 0095-6562 [Print] UNITED STATES
PMID9184738 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Antiemetics
  • Ondansetron
  • Granisetron
  • Adolescent
  • Adult
  • Affect (drug effects)
  • Antiemetics (pharmacology)
  • Cognition (drug effects)
  • Cross-Over Studies
  • Double-Blind Method
  • Drug Monitoring
  • Female
  • Granisetron (pharmacology)
  • Humans
  • Male
  • Nausea (drug therapy, etiology)
  • Ondansetron (pharmacology)
  • Psychomotor Performance (drug effects)
  • Radiotherapy (adverse effects)
  • Vomiting (drug therapy, etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: