[Acute poisoning by new psychotropic drugs].

Abstract

New tricyclic antidepressants such as amineptine and tianeptine have mild toxic effects while amoxapine is very toxic. Poisoning with new selective serotonin reuptake inhibitor antidepressants or monoamine-oxidase inhibitors type A (toloxatone, moclobemide) is usually not severe, but life-threatening serotonin syndromes may appear in case of drug combination with antidepressants. Loxapine and clozapine poisoning may lead to death while risperidone intoxication has usually a rather benign course. Substituted benzamide neuroleptics (amisulpride, sultopride) may induce seizures, QT prolongation and torsades de pointes. New hypnotics such as zolpidem and zopiclone have a mild toxicity similar to that of benzodiazepines, but coma and respiratory depression are observed if other drugs or ethanol are ingested or in case of chronic hepatic or respiratory insufficiency.

• Authors: P Harry
• Journal: La Revue du praticien (Rev Prat) Vol. 47 Issue 7 Pg. 731-5 (Apr 01 1997) ISSN: 0035-2640 [Print] France
• Vernacular Title: Intoxications aiguës par les nouveaux psychotropes.
• PMID: 9183949 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antidepressive Agents, Tricyclic
• Antipsychotic Agents
• Monoamine Oxidase Inhibitors
• Psychotropic Drugs
• Serotonin Uptake Inhibitors

Topics

• Acute Disease
• Antidepressive Agents, Tricyclic (adverse effects)
• Antipsychotic Agents (adverse effects)
• Humans
• Monoamine Oxidase Inhibitors (adverse effects)
• Poisoning (etiology)
• Psychotropic Drugs (adverse effects, classification)
• Selective Serotonin Reuptake Inhibitors (adverse effects)