[Hypercalciuria: etiologies and treatment].

Abstract

Hypercalciuria is a rare biological symptom with multiple possible etiologies in children. Normal calcium excretion rate in children is defined as lower than 4 mg/kg per day, significantly higher values being observed in infants. When using urinary calcium: creatinine ratio, normal values are below 0.22 mg/mg in children, and below 0.6 to 0.8 mg/mg in infants. In our experience half patients with hypercalciuria have idiopathic hypercalciuria. Idiopathic hypercalciuria can be hereditary with a dominant autosomal mode of inheritance. Its pathophysiology is unclear, increased calcium intestinal absorption and impaired renal tubular calcium reabsorption being the two main underlying anomalies. Patients with hypercalciuria should be informed about the risk of urolithiasis and its possible prevention by a high water intake. In those patients with nephrocalcinosis or recurrent episodes of lithiasis, hydrochlorothiazide can be effective in reducing hypercalciuria. However, adverse effects of hydrochlorothiazide on serum lipids have been recently reported and make this treatment questionable in the long term.

• Authors: R Dumas
• Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (Arch Pediatr) Vol. 4 Issue 4 Pg. 351-8 (Apr 1997) ISSN: 0929-693X [Print] France
• Vernacular Title: Les hypercalciuries: étiologies et traitement.
• PMID: 9183409 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Calcium

Topics

• Calcium (urine)
• Calcium Metabolism Disorders (etiology, therapy)
• Child
• Humans