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Hypertriglyceridemia during long-term interferon-alpha therapy in a series of hematologic patients.

Abstract
Adverse reactions to interferon-alpha (IFN-alpha) therapy include flu-like syndrome, bone marrow suppression, neurotoxic effects, and autoimmunity. A slight increase in triglyceride levels has been described less frequently during IFN-alpha administration. The incidence of IFN-alpha-induced hypertriglyceridemia seems variable, and there are no clear data on how to treat it. We report the effect of long-term (more than 12 months) IFN-alpha treatment on triglyceride levels in 43 patients suffering from hairy cell leukemia (18), multiple myeloma (10), chronic myelogenous leukemia (6), cryoglobulinemia (5), non-Hodgkin's lymphoma (3), and Sezary syndrome (1). Hypertriglyceridemia was found in 6 patients (15%). In 3 patients, gemfibrozil restored normal triglyceride values. This study suggests that hypertriglyceridemia is a minor side effect of long-term IFN-alpha therapy and that gemfibrozil might be considered the treatment of choice.
AuthorsD Sgarabotto, F Vianello, P M Stefani, F Scano, R Sartori, A Caenazzo, A Girolami
JournalJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (J Interferon Cytokine Res) Vol. 17 Issue 5 Pg. 241-4 (May 1997) ISSN: 1079-9907 [Print] United States
PMID9181461 (Publication Type: Journal Article)
Chemical References
  • Interferon-alpha
  • Gemfibrozil
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Gemfibrozil (therapeutic use)
  • Humans
  • Hypertriglyceridemia (drug therapy, etiology)
  • Interferon-alpha (adverse effects)
  • Male
  • Middle Aged

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