Abstract |
Adverse reactions to interferon-alpha (IFN-alpha) therapy include flu-like syndrome, bone marrow suppression, neurotoxic effects, and autoimmunity. A slight increase in triglyceride levels has been described less frequently during IFN-alpha administration. The incidence of IFN-alpha-induced hypertriglyceridemia seems variable, and there are no clear data on how to treat it. We report the effect of long-term (more than 12 months) IFN-alpha treatment on triglyceride levels in 43 patients suffering from hairy cell leukemia (18), multiple myeloma (10), chronic myelogenous leukemia (6), cryoglobulinemia (5), non-Hodgkin's lymphoma (3), and Sezary syndrome (1). Hypertriglyceridemia was found in 6 patients (15%). In 3 patients, gemfibrozil restored normal triglyceride values. This study suggests that hypertriglyceridemia is a minor side effect of long-term IFN-alpha therapy and that gemfibrozil might be considered the treatment of choice.
|
Authors | D Sgarabotto, F Vianello, P M Stefani, F Scano, R Sartori, A Caenazzo, A Girolami |
Journal | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
(J Interferon Cytokine Res)
Vol. 17
Issue 5
Pg. 241-4
(May 1997)
ISSN: 1079-9907 [Print] United States |
PMID | 9181461
(Publication Type: Journal Article)
|
Chemical References |
- Interferon-alpha
- Gemfibrozil
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Female
- Gemfibrozil
(therapeutic use)
- Humans
- Hypertriglyceridemia
(drug therapy, etiology)
- Interferon-alpha
(adverse effects)
- Male
- Middle Aged
|