Abstract | BACKGROUND: MATERIALS AND METHODS: Three patients with incurable metastatic breast cancer received 90Y/111In- DOTA- peptide- ChL6 for 5 pharmacokinetics/dosimetry studies and one of these patients also received 2 therapy doses. Quantitative imaging of 111In and in vitro assay of 90Y and 111In in blood urine and bone marrow samples were obtained. RESULTS: 90Y/111In- DOTA- peptide- ChL6 was prepared at high purity and was stable in vivo. Assays of bone marrow revealed no evidence for escape of 90Y or 111In from the chelate. 111In imaging of tumors was excellent, providing a therapeutic index for tumor to marrow radiation as high as 229 to 1. 90Y and 111In provided comparable pharmacokinetics, as did tracer and therapeutic doses of radioimmunoconjugates. One patients that received 2 therapeutic doses of 90Y-DOTA-peptide-ChL6 showed regression of tumors and tumor markers. Toxicities were relatively minor and no anti- globulin response developed despite 5 immunoconjugate infusions. CONCLUSIONS:
|
Authors | S J Denardo, C M Richman, D S Goldstein, S Shen, Q Salako, D L Kukis, C F Meares, A Yuan, J L Welborn, G L Denardo |
Journal | Anticancer research
(Anticancer Res)
1997 May-Jun
Vol. 17
Issue 3B
Pg. 1735-44
ISSN: 0250-7005 [Print] Greece |
PMID | 9179227
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Antibodies, Monoclonal
- Biomarkers, Tumor
- ChL6 monoclonal antibody
- Indium Radioisotopes
- Recombinant Fusion Proteins
- Yttrium Radioisotopes
|
Topics |
- Antibodies, Monoclonal
(pharmacokinetics, therapeutic use)
- Biomarkers, Tumor
(analysis)
- Bone Marrow
(diagnostic imaging)
- Breast Neoplasms
(diagnostic imaging, pathology, radiotherapy)
- Female
- Humans
- Indium Radioisotopes
(pharmacokinetics, therapeutic use)
- Metabolic Clearance Rate
- Neoplasm Metastasis
- Neoplasm Staging
- Radioimmunodetection
(adverse effects)
- Radioimmunotherapy
(adverse effects)
- Recombinant Fusion Proteins
- Tissue Distribution
- Tomography, Emission-Computed
- Tomography, X-Ray Computed
- Yttrium Radioisotopes
(pharmacokinetics, therapeutic use)
|