Cerebrospinal fluid and plasma disposition of yohimbine and 11-hydroxy-yohimbine in young and older healthy subjects, and Alzheimer's disease patients.

Abstract

OBJECTIVE:

The plasma and cerebrospinal fluid (CSF) disposition of yohimbine (YO) and 11-hydroxy-yohimbine (11-OH-YO), after oral administration of a single dose of YO (0.65 mg.kg-1) were studied in young and older healthy subjects and in patients with Alzheimer's disease (AD).

RESULTS:

Plasma disposition of YO displayed large variability; no significant differences among subject groups were observed. In contrast, 11-OH-YO Cmax and AUC were significantly lower in the older normal subjects than in the young normal or AD subjects. A strong positive correlation between CSF and plasma YO concentrations was observed. A weak positive correlation between CSF and plasma concentrations of 11-OH-YO was also observed. CSF to plasma concentration ratios for yohimbine and 11-OH-YO were low (approximately 2%).

• Authors: P A Le Corre, E R Peskind, F Chevanne, M A Raskind, R Le Verge
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 52 Issue 2 Pg. 135-8 ( 1997) ISSN: 0031-6970 [Print] Germany
• PMID: 9174683 (Publication Type: Journal Article)

Chemical References

• Adrenergic alpha-2 Receptor Antagonists
• Adrenergic alpha-Antagonists
• Receptors, Adrenergic, alpha-2
• 11-hydroxyyohimbine
• Yohimbine
• Norepinephrine

Topics

• Adrenergic alpha-2 Receptor Antagonists
• Adrenergic alpha-Antagonists (blood, cerebrospinal fluid, pharmacology)
• Adult
• Aged
• Aging (blood, cerebrospinal fluid)
• Alzheimer Disease (blood, cerebrospinal fluid)
• Female
• Humans
• Male
• Middle Aged
• Norepinephrine (physiology)
• Receptors, Adrenergic, alpha-2 (physiology)
• Reference Values
• Yohimbine (analogs & derivatives, blood, cerebrospinal fluid, pharmacology)