Imaging prostate cancer with technetium-99m-7E11-C5.3 (CYT-351).

Abstract

UNLABELLED:

To evaluate the performance of the 99mTc-labeled monoclonal antibody CYT-351 in visualizing prostate cancer, radioimmunoscintigraphy (RIS) was performed in 35 patients.

METHODS:

Antibody (0.5 mg) labeled with 600 MBq 99mTc was injected intravenously after obtaining informed consent. Planar and SPECT imaging was performed at 10 min and 6-8 and 22-24 hr postinjection. The scans were evaluated for visualization of the primary focus or local recurrence, extraprostatic invasion, lymph node involvement and uptake in bone and soft tissue metastases.

RESULTS:

Thirty-six studies in 35 patients were performed. In 13/14 evaluable studies with clinically localized prostate cancer, RIS had a true-positive rate of 92% (12/13). In eight patients with previous incidental carcinoma detected during transurethral resection undertaken for clinically benign disease, there were 86% true-positive results (6/7) and one true-negative result, which were confirmed by systematic needle biopsies. In six patients with evidence of local recurrence after a previous radical prostatectomy, the true-positive rate was 100% (6/6), which was confirmed by raised or rising prostate-specific antigen levels (PSA) and/or by biopsy. In the eight patients with known metastases, the disease was visualized in 4/4 with progression but not in the 3/3 with regression; one patient demonstrated regressing disease as determined by PSA levels. The overall accuracy was 92%.

CONCLUSION:

RIS with 99mTc CYT-351 is capable of providing good quality images and yielding clinically useful information safely. It has a potentially important clinical role for patients with rising PSA levels but negative images by conventional modalities.

• Authors: V U Chengazi, M R Feneley, D Ellison, M Stalteri, A Granowski, M Granowska, C C Nimmon, S J Mather, R S Kirby, K E Britton
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 38 Issue 5 Pg. 675-82 (May 1997) ISSN: 0161-5505 [Print] United States
• PMID: 9170426 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• CYT-351 monoclonal antibody
• Technetium
• Prostate-Specific Antigen

Topics

• Antibodies, Monoclonal
• Bone Neoplasms (diagnostic imaging, secondary)
• Humans
• Male
• Neoplasm Recurrence, Local (diagnostic imaging)
• Neoplasm Staging
• Prostate (diagnostic imaging)
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (diagnostic imaging, pathology)
• Radioimmunodetection
• Soft Tissue Neoplasms (diagnostic imaging, secondary)
• Technetium
• Tomography, Emission-Computed, Single-Photon