A bioactive seco-rosane diterpenoid from Vellozia candida.

Abstract	Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.
Authors	L M Valente, A A Gunatilaka, D G Kingston, M L Patitucci, A C Pinto
Journal	Journal of natural products (J Nat Prod) Vol. 60 Issue 5 Pg. 478-81 (May 1997) ISSN: 0163-3864 [Print] United States
PMID	9170291 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antimutagenic Agents Coumarins Diterpenes candidalactone
Topics	Antimutagenic Agents (isolation & purification, pharmacology) Coumarins (isolation & purification, pharmacology) DNA Repair Diterpenes (isolation & purification, pharmacology) Magnetic Resonance Spectroscopy Plants, Medicinal (chemistry) Saccharomyces cerevisiae (drug effects, genetics) Spectrophotometry, Infrared Spectrophotometry, Ultraviolet

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