T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis.
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| Abstract |
Increased numbers of T cell receptor (TCR)-gamma/delta cells have been observed in animal models of influenza and sendai virus infections, as well as in patients infected with human immunodeficiency virus and herpes simplex virus type 1 (HSV-1). However, a direct role for TCR-gamma/delta cells in protective immunity for pathogenic viral infection has not been demonstrated. To define the role of TCR-gamma/delta cells in anti-HSV-1 immunity, TCR-alpha-/- mice treated with anti- TCR-gamma/delta monoclonal antibodies or TCR-gamma/delta x TCR-alpha/beta double-deficient mice were infected with HSV-1 by footpad or ocular routes of infection. In both models of HSV-1 infection, TCR-gamma/delta cells limited severe HSV-1-induced epithelial lesions and greatly reduced mortality by preventing the development of lethal viral encephalitis. The observed protection resulted from TCR-gamma/delta cell-mediated arrest of both viral replication and neurovirulence. The demonstration that TCR-gamma/delta cells play an important protective role in murine HSV-1 infections supports their potential contribution to the immune responses in human HSV-1 infection. Thus, this study demonstrates that TCR-gamma/delta cells may play an important regulatory role in human HSV-1 infections.
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| Authors | R Sciammas, P Kodukula, Q Tang, R L Hendricks, J A Bluestone |
| Journal | The Journal of experimental medicine (J Exp Med) Vol. 185 Issue 11 Pg. 1969-75 (Jun 02 1997) ISSN: 0022-1007 [Print] United States |
| PMID | 9166426 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.) |
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