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Fluticasone propionate aqueous nasal spray treatment for perennial allergic rhinitis in children.

AbstractBACKGROUND:
Topical corticosteroid is now accepted as safe and most effective in controlling all symptoms of both allergic and nonallergic rhinitis. Fluticasone propionate aqueous nasal spray is a new once daily topical corticosteroid preparation.
OBJECTIVE:
To evaluate the efficacy and safety of fluticasone propionate in children 5 to 11 years of age with perennial allergic rhinitis.
METHOD:
A double-blind, placebo-controlled, parallel group of 127 recruited patients of whom 106 were evaluated. Treatment with once daily fluticasone propionate 100 micrograms or placebo for 4 weeks followed by a 2-week followup period. Fifty-three patients of each group were treated with fluticasone propionate or placebo by randomized assignment.
RESULTS:
There was no statistical significance of the sex, mean age, weight, and height of the two groups. Patients treated with fluticasone propionate showed a significant decrease in total symptom scores rated by physicians at 2 weeks and 4 weeks, respectively (P < .01, P < .05). The rhinitis symptom scores in treatment group rated by patients (nasal blockage, sneezing, rhinorrhea) were significantly decreased at 2 weeks (P < .05, P < .01). Nasal symptoms as assessed by doctors (turbinate swelling, color of nasal mucosa, secretion, and postnasal drip) also decreased at 2 and 4 weeks, but were not statistically significant, except for the secretion at 2 weeks and postnasal drip at 4 weeks (P < .05). There was no evidence of effects on adrenal function by morning plasma cortisol concentration between the two groups.
CONCLUSION:
Fluticasone propionate was safe and effective in children aged 5 to 11 years with perennial allergic rhinitis.
AuthorsJ Ngamphaiboon, A Thepchatri, P Chatchatee, S Chumdermpadetsuk
JournalAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (Ann Allergy Asthma Immunol) Vol. 78 Issue 5 Pg. 479-84 (May 1997) ISSN: 1081-1206 [Print] United States
PMID9164361 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Aerosols
  • Androstadienes
  • Anti-Allergic Agents
  • Fluticasone
  • Hydrocortisone
Topics
  • Administration, Inhalation
  • Aerosols
  • Androstadienes (administration & dosage, adverse effects, therapeutic use)
  • Anti-Allergic Agents (therapeutic use)
  • Child
  • Child, Preschool
  • Double-Blind Method
  • Female
  • Fluticasone
  • Humans
  • Hydrocortisone (blood)
  • Male
  • Nasal Mucosa (drug effects)
  • Rhinitis, Allergic, Perennial (drug therapy)
  • Time Factors
  • Turbinates (drug effects)

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