Abstract | BACKGROUND: OBJECTIVE: METHOD: A double-blind, placebo-controlled, parallel group of 127 recruited patients of whom 106 were evaluated. Treatment with once daily fluticasone propionate 100 micrograms or placebo for 4 weeks followed by a 2-week followup period. Fifty-three patients of each group were treated with fluticasone propionate or placebo by randomized assignment. RESULTS: There was no statistical significance of the sex, mean age, weight, and height of the two groups. Patients treated with fluticasone propionate showed a significant decrease in total symptom scores rated by physicians at 2 weeks and 4 weeks, respectively (P < .01, P < .05). The rhinitis symptom scores in treatment group rated by patients ( nasal blockage, sneezing, rhinorrhea) were significantly decreased at 2 weeks (P < .05, P < .01). Nasal symptoms as assessed by doctors (turbinate swelling, color of nasal mucosa, secretion, and postnasal drip) also decreased at 2 and 4 weeks, but were not statistically significant, except for the secretion at 2 weeks and postnasal drip at 4 weeks (P < .05). There was no evidence of effects on adrenal function by morning plasma cortisol concentration between the two groups. CONCLUSION:
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Authors | J Ngamphaiboon, A Thepchatri, P Chatchatee, S Chumdermpadetsuk |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 78
Issue 5
Pg. 479-84
(May 1997)
ISSN: 1081-1206 [Print] United States |
PMID | 9164361
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aerosols
- Androstadienes
- Anti-Allergic Agents
- Fluticasone
- Hydrocortisone
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Topics |
- Administration, Inhalation
- Aerosols
- Androstadienes
(administration & dosage, adverse effects, therapeutic use)
- Anti-Allergic Agents
(therapeutic use)
- Child
- Child, Preschool
- Double-Blind Method
- Female
- Fluticasone
- Humans
- Hydrocortisone
(blood)
- Male
- Nasal Mucosa
(drug effects)
- Rhinitis, Allergic, Perennial
(drug therapy)
- Time Factors
- Turbinates
(drug effects)
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