Treatment of dyskeratosis congenita with granulocyte colony-stimulating factor and erythropoietin.

Abstract

Aplastic anaemia is both frequent and difficult to manage in patients with dyskeratosis congenita (DC). We recently treated a 23-year-old male for a year with granulocyte colony-stimulating factor (G-CSF) and erythropoietin (Ep), with an excellent neutrophil response, and a transient effect on haemoglobin levels. G-CSF alone or combined with other cytokines may provide at least a partial effect in pancytopenic patients with DC.

• Authors: B P Alter, F H Gardner, R E Hall
• Journal: British journal of haematology (Br J Haematol) Vol. 97 Issue 2 Pg. 309-11 (May 1997) ISSN: 0007-1048 [Print] England
• PMID: 9163594 (Publication Type: Case Reports, Journal Article)

Chemical References

• Erythropoietin
• Granulocyte Colony-Stimulating Factor

Topics

• Adult
• Anemia, Aplastic (therapy)
• Erythropoietin (therapeutic use)
• Granulocyte Colony-Stimulating Factor (therapeutic use)
• Humans
• Hyperpigmentation (congenital, therapy)
• Male
• Nail Diseases (congenital, therapy)
• Syndrome
• X Chromosome