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Nitroprusside treatment of erythromelalgia in an adolescent female.

AbstractOBJECTIVE:
To report a case of erythromelalgia in an adolescent patient successfully treated with nitroprusside.
CASE SUMMARY:
A 15-year-old girl with erythromelalgia resistant to aspirin therapy received an infusion of nitroprusside. The response of the erythromelalgia to nitroprusside was dramatic, with complete pain resolution within 17 hours after the start of therapy. No relapse of erythromelalgia was seen when nitroprusside was discontinued and the patient remained well after 6 months.
DISCUSSION:
This case adds to existing literature substantiating the benefit of nitroprusside for the treatment of erythromelalgia in pediatric patients. Erythromelalgia in children may represent a different disease entity than that seen in adults, which is commonly responsive to aspirin therapy. The pathogenesis of erythromelalgia is unclear and precludes formulating a proposed mechanism by which nitroprusside has benefit in children.
CONCLUSIONS:
Nitroprusside is valuable for erythromelalgia resistant to aspirin therapy in pediatric patients. Because of unanswered questions regarding the disease, aspirin remains the agent of first choice in all patients with this rare disease.
AuthorsJ D Stone, M P Rivey, D R Allington
JournalThe Annals of pharmacotherapy (Ann Pharmacother) Vol. 31 Issue 5 Pg. 590-2 (May 1997) ISSN: 1060-0280 [Print] United States
PMID9161655 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Analgesics, Non-Narcotic
  • Vasodilator Agents
  • Nitroprusside
  • Aspirin
Topics
  • Adolescent
  • Analgesics, Non-Narcotic (therapeutic use)
  • Aspirin (therapeutic use)
  • Erythromelalgia (drug therapy, rehabilitation)
  • Female
  • Humans
  • Nitroprusside (therapeutic use)
  • Vasodilator Agents (therapeutic use)

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