Bilateral primary renal non-Hodgkin's lymphoma presenting with acute renal failure: successful treatment with systemic chemotherapy.

Abstract

Primary renal non-Hodgkin's lymphoma (NHL) with acute renal failure is a very rare condition, which frequently occurs in bilateral renal involvement. We report a 26-year-old male with primary bilateral renal NHL presenting with acute renal failure. A CT scan of the abdomen showed markedly enlarged kidneys with multinodularity and para-aortic lymphadenopathy. A percutaneous renal biopsy demonstrated 'follicular center lymphoma, diffuse, small cell'. Thirteen cycles of systemic chemotherapy with cyclophosphamide-doxorubicin-vincristine-prednisolone (CHOP) and ifosfamide-methotrexate-etoposide-bleomycin (IMVP-Bleo) regimens were administered, which resulted in normalization of renal function with improvement of renal lymphoma. Since there was no further change of renal lesions after initial partial remission, a follow-up renal biopsy was performed 10 months after diagnosis, and no residual lymphoma was found.

• Authors: J H Choi, G B Choi, K N Shim, S H Sung, W S Han, S Y Baek
• Journal: Acta haematologica (Acta Haematol) Vol. 97 Issue 4 Pg. 231-5 ( 1997) ISSN: 0001-5792 [Print] Switzerland
• PMID: 9158668 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bleomycin
• Vincristine
• Etoposide
• Doxorubicin
• Cyclophosphamide
• Ifosfamide
• Prednisone
• Methotrexate

Topics

• Acute Kidney Injury (etiology)
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Etoposide (administration & dosage)
• Humans
• Ifosfamide (administration & dosage)
• Kidney Neoplasms (complications, drug therapy, pathology)
• Lymphoma, Follicular (complications, drug therapy)
• Male
• Methotrexate (administration & dosage)
• Neoplasms, Multiple Primary (complications, drug therapy, pathology)
• Prednisone (administration & dosage)
• Remission Induction
• Vincristine (administration & dosage)