Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS: There was increased immunoreactivity for laminin, fibronectin, and collagen IV in pial and intracerebral arterioles of untreated hypertensive rats. Immunoreactivity was greatest in arterioles in areas with breakdown of the BBB to serum proteins. Enalapril treatment for 5 weeks resulted in a significant reduction of the mean systolic blood pressure, which was accompanied by attenuation of vascular hypertrophy and attenuation of changes in the vascular extracellular matrix proteins. In addition, there was reduction in the magnitude of BBB breakdown after treatment. CONCLUSIONS:
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Authors | S Nag, D W Kilty |
Journal | Stroke
(Stroke)
Vol. 28
Issue 5
Pg. 1028-34
(May 1997)
ISSN: 0039-2499 [Print] United States |
PMID | 9158646
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Extracellular Matrix Proteins
- Fibronectins
- Enalapril
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Topics |
- Animals
- Antihypertensive Agents
(pharmacology)
- Arterioles
(drug effects, metabolism, pathology)
- Blood Pressure
(drug effects)
- Blood-Brain Barrier
(drug effects)
- Cerebrovascular Circulation
(drug effects)
- Chronic Disease
- Enalapril
(pharmacology)
- Extracellular Matrix Proteins
(metabolism)
- Female
- Fibronectins
(metabolism)
- Hypertension
(metabolism, pathology, physiopathology)
- Rats
- Rats, Wistar
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