[Study of the protective effects of phenothiazine derivatives on a stochastic model of brain compression edema-swelling].

Abstract

Search for pathogenically substantiated drugs to treat and prevent brain edema-swelling (BES) is a topical problem of modern biology and medicine. It is possible to solve this challenging biomedical problem by using a method for devising a stochastic model of the tested process. The developed stochastic model of BES identifies the nerve tissue structural components involving in the anti-edematous mechanism of action of phenothiazine derivatives under the conditions of 7-day brain compression. Analyzing the results of this model application revealed the major governing structures in the morphofunctional complexes under study. The investigations made on the stochastic model yielded a quantitative assessment of the impact of morphofunctional structural relationships under the influence of disturbing factors.

• Authors: I A Platonov
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 1997 Jan-Mar Issue 1 Pg. 12-5 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Issledovanie na stokhasticheskoĭ modeli kompressionnogo oteka-nabukhaniia golovnogo mozga protektivnogo deĭstviia proizvodnykh fenotiazina.
• PMID: 9157371 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antipsychotic Agents
• Neuroprotective Agents
• Phenothiazines

Topics

• Animals
• Antipsychotic Agents (therapeutic use)
• Brain Edema (prevention & control)
• Nerve Compression Syndromes (prevention & control)
• Neuroprotective Agents (therapeutic use)
• Phenothiazines
• Rats
• Stochastic Processes