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The photodynamic effect of Victoria blue BO on peripheral blood mononuclear and leukemic cells.

Abstract
The photodynamic effect of Victoria blue BO (VB-BO) and photoirradiation on peripheral blood mononuclear cells was studied. The cells were preincubated with VB-BO followed by photoirradiation and overnight culture. The highest percentage of dead cells (propidium iodide assay in flow cytometry) was seen in the monocyte population. The lymphocytes showed a lower sensitivity to VB-BO photodynamic action than the monocytes (12% vs 80% of PI-positive cells). The effect of VB-BO and phototreatment on lymphocyte function was studied using a mitogen-induced proliferation assay. A decrease of mitogen response was observed. The VB-BO and photoirradiation were also used on leukemic cells. The leukemic cells from acute myeloid leukemia and B precursors leukemia were sensitive to VB-BO photodynamic action. The high VB-BO sensitivity of monocytes and leukemic cells (myeloid and lymphoid B derived) suggests possible application of VB-BO for selective depletion of monocytes or sensitive leukemic cells.
AuthorsM Fiedorowicz, A Pituch-Noworolska, M Zembala
JournalPhotochemistry and photobiology (Photochem Photobiol) Vol. 65 Issue 5 Pg. 855-61 (May 1997) ISSN: 0031-8655 [Print] United States
PMID9155257 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Antiviral Agents
  • Fluorescent Dyes
  • Photosensitizing Agents
  • Pyrimidinones
  • Quaternary Ammonium Compounds
  • Victoria blue BO
  • merocyanine dye
Topics
  • Antineoplastic Agents (pharmacology)
  • Antiviral Agents (pharmacology)
  • Bone Marrow Cells
  • Cell Survival (drug effects, radiation effects)
  • Fluorescent Dyes
  • Humans
  • In Vitro Techniques
  • Leukemia (pathology)
  • Leukocytes, Mononuclear (drug effects, radiation effects)
  • Monocytes (drug effects, radiation effects)
  • Photochemistry
  • Photosensitizing Agents (pharmacology)
  • Pyrimidinones (pharmacology)
  • Quaternary Ammonium Compounds (pharmacology)
  • Radiation Tolerance (drug effects)

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