Abstract | OBJECTIVE: METHODS: RESULTS:
CT-112 both prevented the development of arthritis in mice treated prophylactically and reduced progression of disease in animals treated therapeutically, and was active when delivered by either subcutaneous injection or oral gavage. No marked immunosuppressive effects were observed during CT-112 treatment, with only moderate decrease in antibody levels and mitogen responses. A significant reduction of the circulating levels of IL-1 was a consistent finding in mice treated therapeutically with CT-112. CONCLUSION: These data suggest PF-4 derived octapeptide exerts antiinflammatory effects of experimental arthritis in mice.
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Authors | P H Wooley, C Schaefer, J D Whalen, J A Dutcher, D F Counts |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 24
Issue 5
Pg. 890-8
(May 1997)
ISSN: 0315-162X [Print] Canada |
PMID | 9150077
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Enzyme Inhibitors
- Lipopolysaccharides
- Mitogens
- Peptide Fragments
- Tetrazolium Salts
- Thiazoles
- Thiazolidinediones
- Concanavalin A
- Platelet Factor 4
- risarestat
- Collagen
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Topics |
- Administration, Oral
- Amino Acid Sequence
- Animals
- Antibody Specificity
- Arthritis, Reactive
(chemically induced, drug therapy, prevention & control)
- Cell Division
(drug effects, immunology)
- Cells, Cultured
- Collagen
(immunology, pharmacology)
- Concanavalin A
(pharmacology)
- Cytokines
(blood)
- Disease Models, Animal
- Enzyme Inhibitors
(immunology)
- Lipopolysaccharides
(pharmacology)
- Mice
- Mice, Inbred DBA
- Mitogens
(pharmacology)
- Peptide Fragments
(analysis)
- Platelet Factor 4
(chemistry, immunology, pharmacology)
- Spleen
(cytology)
- Tetrazolium Salts
- Thiazoles
(immunology)
- Thiazolidinediones
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