Disseminated Burkitt's lymphoma after kidney transplantation: a case report in a boy with Drash syndrome.

Abstract

PURPOSE:

We discuss the clinical, laboratory findings and treatment of a boy who developed Burkitt's lymphoma (BL) after renal transplant and some issues about lymphoproliferative disorders after transplantation.

METHODS:

A 6-year-old boy with Drash syndrome developed disseminated Burkitt's lymphoma 38 months after transplantation for renal failure. Immunosuppressive therapy had consisted of prednisolone and cyclosporine. Polychemotherapy was initiated.

RESULTS:

Polychemotherapy induced rapid and complete remission of the disease without major side effects despite the renal transplant allograft and prolonged immunosuppression.

CONCLUSIONS:

A child with posttransplantation B-cell high-grade lymphoma can be successfully treated with the same chemotherapy regimen used for ordinary cases.

• Authors: A Ferrari, D Perotti, R Giardini, L Ghio, S Riva, M Massimino
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) 1997 Mar-Apr Vol. 19 Issue 2 Pg. 151-5 ISSN: 1077-4114 [Print] United States
• PMID: 9149747 (Publication Type: Case Reports, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Burkitt Lymphoma (drug therapy, etiology, pathology)
• Child
• Humans
• Kidney Transplantation (adverse effects)
• Male
• Nephrotic Syndrome