Abstract | BACKGROUND: Treatment of postinflammatory hyperpigmentation in patients of Fitzpatrick skin types IV, V, and VI is difficult. Glycolic acid peels are useful for pigment dyschromias in caucasians; however, there are no controlled studies examining their safety and efficacy in dark-complexioned individuals. OBJECTIVE: METHODS: Nineteen patients with Fitzpatrick skin type IV, V, or VI were randomized to a control or peel group. The control group applied 2% hydroquinone/10% glycolic acid gel twice daily and 0.05% tretinoin cream at night. The peel patients used the same topical regimen and, in addition, received six serial glycolic acid peels (68% maximum concentration). Patients were evaluated with photography, colorimetry, and subjectively. RESULTS: Sixteen patients completed the study. Both treatment groups demonstrated improvement, but the patients receiving the glycolic acid peels showed a trend toward more rapid and greater improvement. The peel group also experienced increased lightening of the normal skin. CONCLUSIONS: This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark-complexioned individuals.
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Authors | R L Burns, P L Prevost-Blank, M A Lawry, T B Lawry, D T Faria, D P Fivenson |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 23
Issue 3
Pg. 171-4; discussion 175
(Mar 1997)
ISSN: 1076-0512 [Print] United States |
PMID | 9145958
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Glycolates
- Hydroquinones
- Keratolytic Agents
- glycolic acid
- Tretinoin
- hydroquinone
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Topics |
- Administration, Topical
- Adult
- Black People
- Chemexfoliation
- Dermatitis
(complications)
- Drug Combinations
- Female
- Glycolates
(administration & dosage)
- Humans
- Hydroquinones
(administration & dosage)
- Hyperpigmentation
(etiology, therapy)
- Keratolytic Agents
(administration & dosage)
- Middle Aged
- Pilot Projects
- Tretinoin
(administration & dosage)
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